thurnham published the first report of a patient with ectodermal dysplasia in 1848,

What is the history of ectodermal dysplasia?

Although Thurnam published the first report of a patient with ectodermal dysplasia in 1848, the term ectodermal dysplasia was not coined until 1929 by Weech. The ectodermal dysplasias are congenital, diffuse, and nonprogressive. To date, more than 192 distinct disorders have been described.

What is the difference between pure pure ectodermal dysplasia and ectodermal syndromes?

Pure ectodermal dysplasias are manifested by defects in ectodermal structures alone, while ectodermal dysplasia syndromes are defined by the combination of ectodermal defects in association with other anomalies.

What are the tissues involved in ectodermal dysplasia?

The tissues primarily involved are the skin and its appendages (hair follicles, eccrine glands, sebaceous glands, and, nails) and teeth. Although Thurnam published the first report of a patient with ectodermal dysplasia in 1848, the term ectodermal dysplasia was not coined until 1929 by Weech. [1]

What is the prognosis of ectodermal dysplasia?

The prognosis for most patients with ectodermal dysplasia is very good. Morbidity and mortality is related to the absence or dysfunction of eccrine and mucous glands. Beyond early childhood, life expectancy ranges from normal to slightly reduced.

Who discovered ectodermal dysplasia?

In 1838, Wedderburn documented ectodermal dysplasia in a letter to Charles Darwin, describing a case of 10 Hindu male family members. Thurnam in 1848 reported 2 cases of hypohidrotic form. Similar cases were reported by Guilford and Hutchinson in 1883 and 1886 respectively.

When was Anhidrotic ectodermal dysplasia discovered?

The tissues primarily involved are the skin and its appendages (hair follicles, eccrine glands, sebaceous glands, and, nails) and teeth. Although Thurnam published the first report of a patient with ectodermal dysplasia in 1848, the term ectodermal dysplasia was not coined until 1929 by Weech.

What is ectodermal dysplasia?

The ectodermal dysplasias (EDs) are a heterogeneous group of nearly 100 inherited disorders characterized by anomalies in at least two of the structures derived from the embryonic ectoderm, with at least one involving the skin appendages (hair, nails, sweat glands) or teeth.

What is Hypohidrotic ectodermal dysplasia?

Hypohidrotic ectodermal dysplasia (HED) is a rare inherited multisystem disorder that belongs to the group of diseases known as ectodermal dysplasias. Ectodermal dysplasias typically affect the hair, teeth, nails, sweat glands, and/or skin.

Which gene causes ectodermal dysplasia?

Causes. Hypohidrotic ectodermal dysplasia is a genetic condition that can result from mutations in one of several genes. These include EDA, EDAR, EDARADD, and WNT10A. EDA gene mutations are the most common cause of the disorder, accounting for more than half of all cases.

What does Anhidrotic mean?

(AN-hih-DROH-sis) A rare condition in which the sweat glands make little or no sweat. It can affect the whole body or a small part of the body. Anhidrosis may be caused by severe burns, radiation, infection, inflammation, or other injuries to the skin.

What parts of the body does ectodermal dysplasia affect?

There are many types of ectodermal dysplasia (ED), but all of them affect at least two of the ectodermal structures — the skin, hair, nails, teeth, mucous membranes and sweat glands.

What happens to a person with ectodermal dysplasia?

Ectodermal Dysplasia Can Also Cause the Following Medical Issues: Cleft lip and palate. Allergies and immunodeficiencies, such as increased frequencies of asthma, allergies, eczema or rhinitis symptoms. Gastrointestinal issues, such as constipation.

Is ectodermal dysplasia genetic?

All ectodermal dysplasias are genetic disorders, which means that they can be passed on to children by parents.

What condition does Lynn Spirit have?

Hypohidrotic Ectodermal DysplasiaBeing born with a rare skin disease in the black community called Hypohidrotic Ectodermal Dysplasia (HED) meant no teeth, minimal hair, and an inability for Lynn to sweat. His ability to continue to do what he loves — whether it's beauty, Youtube, social media, modelling, dancing — inspires and motivates the masses.

Is ectodermal dysplasia an autoimmune disease?

Abstract. A case is reported of hereditary ectodermal dysplasia with corneal involvement associated with polyendocrinopathy and pernicious anaemia. The presence of autoantibodies to various endocrine organs and ocular tissues is confirmed. This suggests that ectodermal dysplasia may be an autoimmune disease.

How many people are affected by ectodermal dysplasia?

An estimated 3.5 of 10,000 people are affected by ectodermal dysplasia. Ectodermal dysplasias are considered “rare” conditions because they affect less than 200,000 people in the United States. This rarity makes an official study to determine numbers difficult and costly.