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by Mittie Predovic 4 min read

XYREM® Patient Support and Savings | XYREM® for …

6 hours ago The XYREM Coupon Program can cover monthly out-of-pocket expenses, including co-pays and any plan deductible. Eligible patients can pay no more than $35 dollars per prescription, subject to a maximum annual benefit. The XYREM Coupon Program applies to patients who have provided consent to services offered by JazzCares ® for XYREM. >> Go To The Portal

What is the Xyrem Patient Assistance Program?

The XYREM Patient Assistance Program (PAP) is available for those with additional financial needs. If you meet certain financial criteria, such as having a low income level, are uninsured or underinsured, you may be eligible to receive XYREM at no cost.

How do I get a prescription for Xyrem?

XYREM PRESCRIPTION FORM XYREM® (sodium oxybate) oral solution 0.5 g/mL Form available online at www.XYWAVXYREMREMS.com. Either submit online OR print, sign, and: Fax to XYWAV and XYREM REMS: 1-866-470-1744 (toll free) OR mail to XYWAV and XYREM REMS, PO Box 66589, St. Louis, MO 63166-6589.

What are the side effects of Xyrem?

Abuse and misuse of XYREM can cause serious medical problems including seizures, trouble breathing, changes in alertness, coma, and death. XYREM can cause serious side effects including trouble breathing or changes in alertness. Call your doctor right away if you or your child has any of these serious side effects.

How do you use Xyrem syringe?

Hold the XYREM bottle down on the tabletop and firmly press the tip of the syringe into the opening on top of the XYREM bottle. Now hold the bottle and syringe down with one hand and pull up on the plunger with the other hand to draw up your first nightly divided dose.


How long after taking Xyrem can you drive?

Anyone who takes XYREM should not do anything that requires them to be fully awake or is dangerous, including driving a car, using heavy machinery, or flying an airplane, for at least 6 hours after taking XYREM. Those activities should not be done until you know how XYREM affects you or your child.

What is Xyrem GHB?

The active ingredient of XYREM is a form of gamma hydroxybutyrate (GHB). Abuse or misuse of illegal GHB alone or with other CNS depressants (drugs that cause changes in alertness or consciousness) have caused serious side effects.

What are the side effects of XYWAV?

These effects include seizures, trouble breathing (respiratory depression), changes in alertness (drowsiness), coma, and death. Call your doctor right away if you or your child has any of these serious side effects. Because of these risks, you have to go through the XYWAV and XYREM REMS.

Can you take Xyrem with Xywav?

You or your child must be enrolled in the XYWAV and XYREM REMS to receive XYREM. Do not take XYREM if you take or your child takes other sleep medicines or sedatives (medicines that cause sleepiness), drink alcohol, or have a rare problem called succinic semialdehyde dehydrogenase deficiency.

Can Xyrem cause physical dependence?

Your side effects may increase when you take higher doses of XYREM. XYREM can cause physical dependence and craving for the medicine when it is not taken as directed. These are not all the possible side effects of XYREM. You are encouraged to report negative side effects of prescription drugs to the FDA.

Does Xyrem cause breathing problems?

XYREM can cause serious side effects, including the following: Breathing problems, includingslower breathing, trouble breathing, and/or short periods of not breathing while sleeping (sleep apnea). People who already have breathing or lung problems have a higher chance of having breathing problems when they take XYREM.

Does Xyrem cause sleepiness?

The most common side effects of XYREM in adults include nausea, sleepiness, dizziness, vomiting, bedwetting, and tremor. The most common side effects of XYREM in children include, nausea, bedwetting, vomiting, headache, weight decreased, decreased appetite, dizziness and sleepwalking.

How long does it take to fall asleep after taking Xyrem?

XYREM can cause sleep very quickly. Some people fall asleep within 5 minutes, and most people fall asleep within about 15 minutes. That is why you need to be in bed for each dose.

How to prepare Xyrem for night?

To prepare the dosage each night, you need: 1 bottle of XYREM. (the size and shape may vary, but the method of dispensing is always the same) 2 empty pharmacy containers with child-resistant caps. 1 XYREM measuring syringe.

How long after mixing Xyrem can you use it?

The doses should be out of the reach of children and pets. If for some reason you do not use a XYREM dose within 24 hours of mixing it with water, throw it away. See Instructions for Use in the Medication Guide. Learning anything new takes time.

Does Xyrem contain water?

All shipped bottles of XYREM contain the concentrated medicine. Water for mixing the medicine is not provided in the shipment. Repeat these steps when preparing your second dose. Be careful to add only water to each container and not more XYREM. All shipped bottles of XYREM contain the concentrated medicine.

Can you mix Xyrem with water?

Be careful to add only water to each container and not more XYREM. All shipped bottles of XYREM contain the concentrated medicine. Water for mixing the medicine is not provided in the shipment. See Instructions for Use in the Medication Guide.

Starting and Titrating XYREM in Adults 1

Patients should be assessed frequently for symptom response and adverse reactions.

Important Safety Information

Dose-Response Information: In clinical trials in adult patients with narcolepsy, a dose-response relationship was observed for nausea, vomiting, paresthesia, disorientation, irritability, disturbance in attention, feeling drunk, sleepwalking, and enuresis. The incidence of all these reactions was notably higher at 9 g per night.

How to contact Xyrem?

Please call your healthcare provider if you have questions about XYREM, or you can contact the REMS toll free at 1-866-997-3688. You can reach a pharmacist at this number 24 hours a day, 7 days a week with any questions.

What are the side effects of Xyrem?

The most common side effects with XYREM are nausea, dizziness, throwing up, bedwetting, and diarrhea. Side effects may increase with higher doses. These are not the only possible side effects with XYREM. If you are worried about any possible side effects with XYREM, talk with your healthcare provider or the pharmacist at the REMS.

What is Xyrem used for?

XYREM is a prescription medicine used to treat patients 7 years of age and older with narcolepsy to reduce too much daytime sleepiness and to reduce cataplexy (suddenly weak or paralyzed muscles). IMPORTANT INFORMATION ABOUT XYREM INCLUDES THE FOLLOWING: .

Why do you need to enroll in REMs?

Enrollment in the REMS by prescribers and patients is required by the FDA to ensure the benefits of XYREM outweigh the risks associated with XYREM. You are enrolled in the program when your healthcare provider sends in the enrollment form you signed.

How long after taking Xyrem should I be awake?

You may need to set an alarm to awaken for the second dose  Do not drive a car, use heavy machinery, fly an airplane, or do anything that is dangerous or that requires you to be alert for the first 6 hours after taking XYREM.

How to get a syringe out of a bottle?

Place the bottle on a hard, flat surface and grip the bottle with one hand and firmly press the syringe into the center opening of the bottle with the other. Pull back on the plunger until the medication flows into the syringe and the liquid level is aligned with the corresponding tick mark for your dose.

Can you drink alcohol while taking Xyrem?

When taking XYREM, do not drink alcohol or take other medicines that slow your breathing or mental activity or make you sleepy. You could have serious side effects