norpace patient report

Precautions

Does Norpace make you gain weight?

shortness of breath (even with mild exertion), swelling, rapid weight gain; or. low blood sugar (headache, hunger, weakness, sweating, confusion, irritability, dizziness, fast heart rate, or feeling jittery).

What is Norpace used to treat?

This medication is used to treat certain types of serious (possibly fatal) irregular heartbeat, such as ventricular tachycardia that doesn't stop. It is used to restore normal heart rhythm and maintain a regular, steady heartbeat. Disopyramide is known as an anti-arrhythmic drug.

What are the side effects of Norpace?

In certain people, disopyramide (Norpace) can cause low blood sugar. Make sure to watch out for symptoms of low blood sugar, including shakiness, dizziness, sweating, difficulty concentrating, or feeling moody.

What company makes Norpace?

NORPACE® and NORPACE® CR | Pfizer.

Should Norpace be taken with food?

HOW TO USE: Take this medication by mouth with or without food exactly as prescribed by your doctor. If you are taking the immediate-release form, you will usually take it 4 times daily or as directed by your doctor.

Is there a generic for Norpace?

No. There is currently no therapeutically equivalent version of Norpace CR available in the United States. Note: Fraudulent online pharmacies may attempt to sell an illegal generic version of Norpace CR. These medications may be counterfeit and potentially unsafe.

What is the best medicine for the heart?

Modern heart drug therapy includes the following “big six” medications:Statins — to lower LDL cholesterol. ... Aspirin — to prevent blood clots. ... Clopidogrel — to prevent blood clots. ... Warfarin — to prevent blood clots. ... Beta-blockers — to treat heart attack and heart failure and sometimes used to lower blood pressure.More items...•

Does disopyramide cause fatigue?

General body symptoms of fatigue, muscle weakness, malaise, and aches/pains have been reported in 3% to 9% of patients administered disopyramide. Rarely, fever has occurred.

How often should you take disopyramide?

Disopyramide capsules may be taken every 6 or 8 hours. The extended-release capsule is usually taken every 12 hours. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take disopyramide exactly as directed.

What class of drug is quinidine?

Quinidine is in a class of medications called antiarrhythmic medications.

Is there a shortage of disopyramide?

Department of Health and Social Care (DHSC) has issued a Medicine Supply Notification (MSN) for Disopyramide 100mg and 150mg capsules. Supplies of disopyramide 100mg capsules are very limited until the end of March 2022. Disopyramide 150mg capsules are out of stock until the end of March 2022.

When is Norpace CR available?

Company Contact Information:PresentationAvailability and Estimated Shortage DurationShortage Reason (per FDASIA)Norpace CR, 150 mg capsules, bottle of 100 (NDC 0025-2742-31)AvailableOther100 mg capsules, bottle of 100 (NDC 59762-0386-1)Next Delivery: June 2022; Estimated Recovery: July 2022Other4 more rows•Mar 19, 2021

Before using Norpace

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Proper use of Norpace

This section provides information on the proper use of a number of products that contain disopyramide. It may not be specific to Norpace. Please read with care.

Precautions while using Norpace

Your doctor should check your progress at regular visits to make sure the medicine is working properly.

Norpace side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

What is Norpace CR?

Norpace and Norpace CR are indicated for the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, that, in the judgment of the physician, are life-threatening....

How much norpace is in a capsule?

Norpace (disopyramide phosphate) is supplied in hard gelatin capsules containing either 100 mg or 150 mg of disopyramide base, present as the phosphate.

What is Norpace a type 1 drug?

Norpace (disopyramide phosphate) is a Type 1 antiarrhythmic drug (i.e., similar to procainamide and quinidine)....

How much disopyramide is in Norpace?

Norpace (disopyramide phosphate) is an antiarrhythmic drug available for oral administration in immediate-release and controlled-release capsules containing 100 mg or 150 mg of disopyramide base, present as the...

What is the Pfizer Rxpathways number?

Patients and physicians can contact RxPathways at (866) 706-2400 or visit the website for more information on these programs www.pfizerrxpathways.com.

How to report adverse events to FDA?

Food and Drug Administration (FDA) directly to report adverse events or product quality concerns either online at https://vaers.hhs.gov or call (800) 822-7967.

How to report a drug to the FDA?

You may also report to the U.S. Food and Drug Administration (FDA) by visiting www.fda.gov/medwatch or by calling the U.S. FDA at (800)-332-1088.

What is Norpace CR?

Norpace and Norpace CR are indicated for the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, that, in the judgment of the physician, are life-threatening....

How much norpace is in a capsule?

Norpace (disopyramide phosphate) is supplied in hard gelatin capsules containing either 100 mg or 150 mg of disopyramide base, present as the phosphate.

What is Norpace a type 1 drug?

Norpace (disopyramide phosphate) is a Type 1 antiarrhythmic drug (i.e., similar to procainamide and quinidine)....

How much disopyramide is in Norpace?

Norpace (disopyramide phosphate) is an antiarrhythmic drug available for oral administration in immediate-release and controlled-release capsules containing 100 mg or 150 mg of disopyramide base, present as the...

Can Norpace be used with quinidine?

The concomitant use of Norpace or Norpace CR with other Type 1A antiarrhythmic agents (such as quinidine or procainamide), Type 1C antiarrhythmics (such as encainide, flecainide or propafenone), and/or propranolol should be reserved for patients with life-threatening arrhythmias who are demonstrably unresponsive to single-agent antiarrhythmic therapy. Such use may produce serious negative inotropic effects, or may excessively prolong conduction. This should be considered particularly in patients with any degree of cardiac decompensation or those with a prior history thereof. Patients receiving more than one antiarrhythmic drug must be carefully monitored.

Does norpace lower glucose?

In rare instances significant lowering of blood-glucose values has been reported during Norpace administration. The physician should be alert to this possibility, especially in patients with congestive heart failure, chronic malnutrition, hepatic, renal or other diseases, or drugs (e.g., beta-adrenoceptor blockers, alcohol) which could compromise preservation of the normal glucoregulatory mechanisms in the absence of food. In these patients the blood-glucose levels should be carefully followed.

Can Norpace cause heart failure?

Norpace or Norpace CR may cause or worsen congestive heart failure or produce severe hypotension as a consequence of its negative inotropic properties. Hypotension has been observed primarily in patients with primary cardiomyopathy or inadequately compensated congestive heart failure. Norpace or Norpace CR should not be used in patients with uncompensated or marginally compensated congestive heart failure or hypotension unless the congestive heart failure or hypotension is secondary to cardiac arrhythmia. Patients with a history of heart failure may be treated with Norpace or Norpace CR, but careful attention must be given to the maintenance of cardiac function, including optimal digitalization. If hypotension occurs or congestive heart failure worsens, Norpace or Norpace CR should be discontinued and, if necessary, restarted at a lower dosage only after adequate cardiac compensation has been established.

What are the most common adverse reactions to Norpace?

The most serious adverse reactions are hypotension and congestive heart failure. The most common adverse reactions, which are dose dependent, are associated with the anticholinergic properties of the drug. These may be transitory, but may be persistent or can be severe. Urinary retention is the most serious anticholinergic effect.

What drugs interact with Norpace?

What Drugs, Substances, or Supplements Interact with Norpace? Norpace may interact with other anti-arrhythmics, beta-blockers, erythromycin, clarithromycin, phenytoin, phenobarbital, cisapride, rifampin, or warfarin. Tell your doctor all medications you use.

What are the side effects of a syringe?

dry mouth, nose, or throat; nausea, stomach pain, bloating; constipation; dry eyes, blurred vision; headache, tiredness, general ill feeling; or. muscle pain or weakness. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Can Norpace cause early labor?

Norpace During Pregnancy and Breastfeeding. During pregnancy, Norpace should be used only when prescribed. Rarely, this drug may cause early labor during pregnancy. Discuss the risks and benefits with your doctor. This medication passes into breast milk, and the effect on a nursing infant is unknown.

Does Norpace cause hypoglycemia?

Hypoglycemia has been reported in association with Norpace administration (see WARNINGS ).

Most voted positive review

I cannot go out in the heat, while on this med. I use a cooling vest when it is between 80 and 90 degrees. I have had bad breakthroughs of afib/tachy when ill or over heated or in temps of over 90 degrees, even with the cooling vest. I had been using calan only for about five years and it just stopped working for me.

Most voted negative review

I have experienced extreme fatigue, light headedness and crying bouts while on this drug. I am 37 yrs old and this medication not only has life altering side effects but restrictions also that do not fit into my active lifestyle.

Shared reviews and ratings

I have only been on this medication only a short time, but thus far the effect has been dramatic. For the first time in several years, I am symptom free (highly irregular heartbeats, both in frequency and intensity) with only mild gastrointestinal side effects.

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Who can provide more information about disopyramide?

Your pharmacist can provide more information about disopyramide.

Can you skip a dose of disopyramide?

Do not skip doses or change your dosing schedule without your doctor's advice. Sudden changes in the way you take disopyramide can make your condition worse.

DESCRIPTION

Norpace (disopyramide phosphate) is an antiarrhythmic drug available for oral administration in immediate-release and controlled-release capsules containing 100 mg or 150 mg of disopyramide base, present as the phosphate. The base content of the phosphate salt is 77.6%. The structural formula of Norpace is:

CLINICAL PHARMACOLOGY

Norpace (disopyramide phosphate) is a Type 1 antiarrhythmic drug (i.e., similar to procainamide and quinidine).

INDICATIONS AND USAGE

Norpace and Norpace CR are indicated for the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, that, in the judgment of the physician, are life-threatening. Because of the proarrhythmic effects of Norpace and Norpace CR, their use with lesser arrhythmias is generally not recommended.

CONTRAINDICATIONS

Norpace and Norpace CR are contraindicated in the presence of cardiogenic shock, preexisting second-or third-degree AV block (if no pacemaker is present), congenital Q-T prolongation, or known hypersensitivity to the drug.

Warnings

In the National Heart, Lung and Blood Institute's Cardiac Arrhythmia Suppression Trial (CAST), a long-term, multi-center, randomized, double-blind study in patients with asymptomatic non-life-threatening ventricular arrhythmias who had had a myocardial infarction more than 6 days but less than 2 years previously, an excessive mortality or non-fatal cardiac arrest rate (7.7%) was seen in patients treated with encainide or flecainide compared with that seen in patients assigned to carefully matched placebo-treated groups (3.0%).

ADVERSE REACTIONS

The adverse reactions which were reported in Norpace clinical trials encompass observations in 1,500 patients, including 90 patients studied for at least 4 years. The most serious adverse reactions are hypotension and congestive heart failure.

OVERDOSAGE

Deliberate or accidental overdosage of oral disopyramide may be followed by apnea, loss of consciousness, cardiac arrhythmias, and loss of spontaneous respiration. Death has occurred following overdosage.

Commonly Used Brand Name

Uses For Norpace

Before Using Norpace

Proper Use of Norpace

Precautions While Using Norpace

Norpace Side Effects

Further Information