21 hours ago Introduction: The COLO-COHORT study aims to produce a multi-factorial risk prediction model for colorectal neoplasia that will be able to be used to target colonoscopy to those at greatest risk of colorectal neoplasia, ensuring that people are not investigated unnecessarily and maximising the use of limited endoscopy resources. The study will also explore the link between neoplasia and … >> Go To The Portal
Progress of follow-up of participants of the Colon Cancer Family Registry Cohort (as of June 2017). Participation is defined as the percentage of those who were alive at contact attempt who completed the questionnaire. The total number of person-years of follow-up by participants who completed a follow-up questionnaire is 276 762 person-years.
Profile in a nutshell The Colon Cancer Family Registry Cohort (CCFRC) was established for the purpose of research on the genetic and environmental aetiology of colorectal cancer. The 42 489 study participants from 15 049 families were recruited between 1998 and 2012 in the USA, Canada, Australia and New Zealand.
et al. Pathology features in Bethesda guidelines predict colorectal cancer microsatellite instability: a population-based study. Gastroenterology2007;133:48–56.
et al. Variants on 9p24 and 8q24 are associated with risk of colorectal cancer: results from the Colon Cancer Family Registry. Cancer Res2007;67:11128–32.
Conclusions: The greatest needs for intervention are among survivors of rectal cancer, survivors of minority racial/ethnic background, and survivors of younger age. Survivors with low educational attainment and those with higher stage disease could also benefit.
Survivors of rectal cancer reported more needs than respondents with colon cancer; persons of color reported more needs than non-Hispanic whites; individuals without high school diplomas reported more needs than individuals with more education. Fear of recurrence was the most common health/lifestyle concern (58.9%).