30 hours ago · Patients who have IgM antibodies against dengue virus detected in their serum specimen with an IgM antibody test and either: 1) have a negative NAAT or NS1 result in the acute phase specimen, or 2) without an acute phase specimen, are classified as having a presumptive, recent dengue virus infection. >> Go To The Portal
Interpreting a dengue blood report is not a difficult task. The reports usually contain the dengue normal value in front of the values obtained through the test. You can easily check and compare them with the normal values.The result of the whole test is found negative in the initial stage of dengue fever
A mosquito borne viral disease.
IgM Result | IgG Result | Possible Interpretation |
---|---|---|
Positive | Negative | Current infection |
Positive | Positive | Current infection |
Low or negative or not tested | Four-fold increase in samples taken 2-4 weeks apart | Recent infection |
Low or negative | Positive | Past infection |
Key Facts
REASON FOR TESTING OF DENGUE
The prognosis for dengue is usually good. The worst symptoms of the illness typically last 1 to 2 weeks, and most patients will fully recover within several additional weeks. Typical dengue infection is fatal in less than 1% of cases; however, the more severe dengue hemorrhagic fever is fatal in 2.5% of cases.
Immunoglobulin M (IgM) This test looks for IgM (antibodies) in the blood, which appear in the early course of the disease (acute infection). The test can also help to differentiate between primary (first time infection) and secondary (second time infection with any of the dengue virus) infection.
If an infection is suspected, you will get a blood test to check for the dengue virus. During a blood test, a health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial.
IgG as a sero-marker of Dengue infection. If the IgG is positive but the IgM is low or negative, then it is likely that the patient had an infection sometime in the past. Presence of IgG alone (absence of NS1 Ag and/or IgM), does not indicate active dengue infection.
The clinical presentation of dengue patients is acute febrile illness with no localizing signs and symptoms which may mimic other infections. Therefore the laboratory tests such as a complete blood count (CBC), serological test or blood culture need to be used to differential and confirm the diagnosis.
Dengue fever is characterized by leucopenia (White Blood Cells (WBC) < 5000 cells/mm3), thrombocytopenia (< 150,000 cells/mm3), rising haematocrit (5–10%) and there should be no evidence of plasma leakage [10].
Reference Range: Dengue Fever Virus Antibody, IgG 1.64 IV or less: Negative - No significant level of detectable dengue fever virus IgG antibody. 1.65-2.84 IV: Equivocal - Questionable presence of antibodies. Repeat testing in 10-14 days may be helpful.
Dengue Antigen NS1, IgG and IgM test detects the non-structural protein component (NS1) of the dengue virus and the antibodies (IgG & IgM) produced by the body in response to the infection. NS1 and IgM is secreted into the blood during dengue infection and are detectable within 3-4 days of illness.
CRP levels in patients with dengue were higher than patients with potential viral infection but lower than patients with potential bacterial infection, resulting in a quadratic association between dengue diagnosis and CRP, with levels of approximately 30 mg/L associated with the highest risk of having dengue.
Positive IgM and IgG tests for dengue antibodies detected in an initial blood sample mean that it is likely that the person became infected with dengue virus within recent weeks. IgM antibody tests can be positive if a person has been infected with a similar virus, such as chikungunya (called cross-reaction).
Dengue fever can result in a drop in your white blood cell and platelet counts. The normal platelet count in the body ranges from 1.5 to 4 lacs, this can go down to as low as 20,000 to 40,000 in the case of dengue patients.
The normal number of WBCs in the blood is 4,500 to 11,000 WBCs per microliter (4.5 to 11.0 × 109/L). Normal value ranges may vary slightly among different labs. Some labs use different measurements or may test different specimens.
This study may suggest that leukopenia in dengue fever may be caused by virus-induced destruction or inhibition of myeloid progenitor cells. Thrombocytopenia may result from by destruction of peripheral platelet or bone marrow megakaryocytes by viruses which consequently reduce the platelet production.