polycythemia patient case report

Polycythemia vera in an oral surgical patient. A case report Polycythemia vera is a stem cell disorder that results in an increase in the production of red blood cells. Although numerous mechanisms have been suggested, the cause of the disease is unknown. Diagnosis is based on clinical and laboratory presentation.

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What is the prevalence of primary polycythemia?

Primary polycythemia is usually associated with a gene mutation of the JAK2 (Janus kinase 2) gene. It affects 1 to 2 persons per 100,000, it has a prevalence of 22 persons per 100,000.

What is polycythemia and what causes it?

Polycythemia is one of several “myeloproliferative neoplasms (MPNs), a term used to group a number of blood cancers results from uncontrolled clonal production, especially red cells, as a result of acquired mutations in an early blood-forming cell. Primary polycythemia is usually associated with a gene mutation of the JAK2 (Janus kinase 2) gene.

Is polycythemia vera a risk factor for cerebral infarction?

Polycythemia vera (PV) is a cloned erythrocytotic disease manifested by high proliferation and apoptosis in the bone marrow. The clinical symptoms of PV are occult. In practice, patients with cerebral infarction caused by PV are prone to misdiagnosis and missed diagnosis. Here, we report a misdiagnosis of PV leading to cerebral infarction.

Does polycythemia vera affect oral health care?

Polycythemia Vera and Dental Treatment Primary polycythemia and its comorbidities have implications for oral health care. Precautionary measures, such as blood tests, may be required before oral healthcare is undertaken and a close communication and cooperation is required between the treating hematologist and the oral healthcare provider.

How many cases of polycythemia vera are there?

Polycythemia vera affects slightly more men than women. The disorder is estimated to affect approximately 44 to 57 per 100,000 people in the US. It occurs most often in individuals more than 60 years old, but can affect individuals of any age. It is extremely rare in individuals under 20.

Who is most affected by polycythemia?

Polycythemia vera can occur at any age, but it's more common in adults between 50 and 75. Men are more likely to get polycythemia vera, but women tend to get the disease at younger ages.

What are the effects of polycythemia on a patient?

Polycythemia vera can be fatal if not diagnosed and treated. It can cause blood clots resulting in a heart attack, stroke, or pulmonary embolism. Liver and spleen enlargement are other possible complications.

How can you tell if a person has polycythemia?

How polycythaemia is diagnosed. Polycythaemia can be diagnosed by carrying out a blood test to check: the number of red blood cells in your blood (red blood cell count) the amount of space the red blood cells take up in the blood (haematocrit level)

How long can you live with PV?

Median survival in patients with polycythemia vera (PV), which is 1.5-3 years in the absence of therapy, has been extended to approximately 14 years overall, and to 24 years for patients younger than 60 years of age, because of new therapeutic tools.

Can polycythemia patients donate blood?

As a Polycythemia Vera patient, you can not give blood to the Red Cross. You can go to blood centers where they will accept blood from a PV patient for what is referred to as “therapeutic phlebotomy.” You will need to check with the respective blood center in your area.

Which is a major complication of polycythemia?

Polycythemia Vera Complications Blood clots are the most serious complication of PV. Blood clots can cause a heart attack or stroke. They also can cause your liver and spleen to enlarge. Blood clots in the liver and spleen can cause sudden, intense pain.

What are the most common symptoms of polycythemia?

Symptomsblurred vision.fatigue.reddish or purplish skin on the palms, earlobes, and nose.bleeding or bruising.a burning sensation in the feet.abdominal fullness.frequent nosebleeds.bleeding gums.More items...•

What is the main cause of death in polycythemia?

Blood clots are the most common cause of death in people with PV. When blood clots form in blood vessels, they can block the flow of blood to vital organs. This can lead to life threatening complications, such as stroke, heart attack, and venous thrombosis.

How much hemoglobin is too high?

The threshold for a high hemoglobin count differs slightly from one medical practice to another. It's generally defined as more than 16.6 grams (g) of hemoglobin per deciliter (dL) of blood for men and 15 g/dL for women.

Can you fly with polycythemia?

As you may know, certain MPNs, like PV and ET, are already associated with a potential for blood clots. This is why it's important for people with MPNs to be mindful when flying. To keep your circulation moving, stretch your legs, wiggle your toes and get up every so often and walk around the cabin.