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Pathologic complete response (pCR) refers to the absence of invasive/in situ cancer in the breast and/or axillary lymph nodes [25,26,27]. Achieving pCR following neoadjuvant chemotherapy (NACT) is a desirable outcome, frequently leading to improved survival [28,29].
As you find your way along, cancer journey support groups can be excellent resources not only for the information they provide but for the camaraderie of spirit they offer. They can also be helpful at the end of treatment as you find yourself readjusting to everyday life again.
If you have been diagnosed with cancer, it’s important to prepare for any potential treatment ahead. Even taking small steps can improve your sense of well-being and control.
If you are a new patient, we ask you to please review and complete our new patient forms before your first appointment. Thoroughness and accuracy are essential when completing your forms, especially your family history questionnaire.
Our healthcare practitioners are encouraged to utilize telemedicine when appropriate to replace in-person healthcare visits. Your cancer care provider will determine whether it is appropriate for you to be seen via telemedicine or whether an in-person visit is necessary.
a pathological complete response (pCR)). But, past this, as noted by FDA experts Tatiana Prowell and Patricia Cortazar of the FDA's Breast Oncology Group [1], the definition of pCR itself has no universal consensus: it may be construed as:
Loco-regionally advance breast cancer are recommended to start treatment with Neo-Adjuvant Chemotherapy (NACT). This leads to resolution/ regression of tumour in body inclusding Breast and Axilla, Supra clavicular region.
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2. pCR is also considered as surrogate marker for better survival for breast cancer patients.
Furthermore, there is no standard method for grading pathological response of breast tumors to neoadjuvant chemotherapy and a number of different classification systems have been proposed [2,3,4,5,6,7]. Most, but not all, of these grading schemes have included both no residual disease of any sort and residual ductal carcinoma in situ (DCIS) without invasive disease in the definition of pCR, that is, they allowed for residual DCIS as long as there was otherwise no residual histological evidence of tumor.
showing that some investigators evaluate pCR based on the state of the primary lesion alone , whereas others evaluate it based on the states of both the primary lesion and axillary lymph nodes , and investigators are also split has to whether in situ disease (DCIS) is allowed or not.
Pathological complete response is a very important marker after chemotherapy. I want to understand what is the meaning of it.
Pathologic complete response (pCR) refers to the absence of invasive/in situ cancer in the breast and/or axillary lymph nodes [25,26,27]. Achieving pCR following neoadjuvant chemotherapy (NACT) is a desirable outcome, frequently leading to improved survival [28,29]. This is especially relevant in the modern era with the introduction of HER2targeted therapies and the more frequent use of anthracyclin + taxanes vs. cyclophosphamide/methotrexate/5-fluorouracil (CMF) [30,31,32,33,34]. However, the extent of this benefit appears to vary by biologic subtypes [26]. In contrast to breast cancer as a whole, IBC is a comparatively rare malignancy and has not been well characterized by biologic subtypes, pCR and associated outcomes [35,36]. We undertook this study to examine pCR and OS of IBC, based on different biologic subtypes.
Patients with pCR following neoadjuvant therapy (5-year survival).
The median age of women at diagnosis was 56 years (n= 8550; IQR = 18) (Table 1). On average, they were followed for a median of 3.7 years [IQR = 4.3]. Over half of the patients had private health insurance and lived more than nine miles from their treatment facility, which in most cases was a comprehensive community cancer center (47%). White race was the predominant group within each biologic subtype (≥80%). Less than 4% of patients were classified as “other race”. Approximately 8% of the sample were Hispanic ethnicity. Independent of biologic subtype, over 80% of our patients presented with no significant comorbidities (CCI score = 0).
4Priority Research Centre for Generational Health and Ageing (PRCGHA), School of Medicine and Public Health, The University of Newcastle (UoN), Newcastle 2308, Australia
Increasingly, pCR is being used as a short-term endpoint in neoadjuvant clinical trials, given its prognostic association with longer-term outcomes [52].
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