patient report for rivastigmine

Precautions

If you develop a skin rash, hives, or any allergic reaction to rivastigmine, stop taking the medicine and check with your doctor as soon as possible. Before you have any kind of surgery, dental treatment, or emergency treatment, tell the medical doctor or dentist in charge that you are taking rivastigmine.

What should I know about rivastigmine before taking it?

Patients' age, gender, or race did not predict clinical outcome of Rivastigmine tartrate treatment. Rivastigmine tartrate capsules, USP equivalent to 1.5 mg, 3 mg, 4.5 mg, or 6 mg of Rivastigmine base are available as follows:

Does patient age predict clinical outcome of Rivastigmine tartrate treatment?

It has an apparent volume of distribution (V D) in the range of 1.8 to 2.7 L/kg. Rivastigmine is rapidly and extensively metabolized, primarily via cholinesterase-mediated hydrolysis to the decarbamylated metabolite.

What is the volume of distribution of rivastigmine?

Although not observed in clinical trials of Rivastigmine, drugs that increase cholinergic activity may cause urinary obstruction. Drugs that increase cholinergic activity, including Rivastigmine, should be used with care in patients with a history of asthma or obstructive pulmonary disease.

Does rivastigmine cause urinary obstruction?

What should you assess before giving rivastigmine?

Before taking rivastigmine, Ask your pharmacist for a list of the ingredients. tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take.

What's a common side effect of rivastigmine?

Rivastigmine may cause nausea, vomiting, diarrhea, stomach pain, loss of appetite, or weight loss. Tell your doctor if any of these problems are severe, because they could cause other health problems such as dehydration.

What is the indication of rivastigmine?

With its approval by the FDA in 1997, rivastigmine is indicated to treat mild to moderate dementia of the Alzheimer's type. Its indications also include the treatment of mild to moderate dementia that is associated with Parkinson disease.

How effective is rivastigmine for Alzheimer's disease?

Rivastigmine is well tolerated and effective. It improves cognition, participation in activities of daily living, and global evaluation ratings in patients with mild to moderately severe Alzheimer's disease. This is the first treatment to show compelling evidence of efficacy in a predominantly European population.

What are the contraindications of rivastigmine?

Rivastigmine patch is contraindicated in patients who have a history of application site reactions with rivastigmine patch suggestive of allergic contact dermatitis. In patients currently receiving transdermal rivastigmine, discontinue treatment if allergic contact dermatitis is suspected.

Does rivastigmine cause low blood pressure?

A drug called rivastigmine is used to reduce symptoms and improve their behavior. But more than 53% of these patients develop orthostatic hypotension (OT).

How does rivastigmine work in the body?

Rivastigmine, an acetylcholinesterase inhibitor, works by increasing the levels of a brain chemical called acetylcholine which allows the nerve cells to communicate. This may improve the symptoms of dementia. Rivastigmine can be taken orally, either as capsules or a liquid, or by applying a patch on the skin.

Can rivastigmine cause hallucinations?

According to our knowledge and literature review, this is the first reported case in which transdermal administration of rivastigmine lead to visual hallucinations.

Does rivastigmine affect sleep?

According to our observation, donepezil and rivastigmine have no negative effect on sleep by any means.

Does rivastigmine improve memory?

Rivastigmine is in a class of medications called cholinesterase inhibitors. It improves mental function (such as memory and thinking) by increasing the amount of a certain natural substance in the brain.

Does rivastigmine slow down dementia?

Rivastigmine is an acetylcholinesterase inhibitor. It slows the breakdown of ACh, so it can build up and have a greater effect. However, as Alzheimer's disease gets worse, there will be less and less ACh, so rivastigmine may not work as well. This medicine is available only with your doctor's prescription.

Does rivastigmine slow the progression of dementia?

Rivastigmine may slow AD progression, allowing patients to maintain autonomy for longer.

What are the side effects of rivastigmine?

Rivastigmine side effects. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: severe or ongoing vomiting or diarrhea, loss of appetite, weight loss;

How long to take alzheimer patch?

MILD TO MODERATE ALZHEIMER'S DISEASE:#N#ORAL:#N#-Initial dose: 1.5 mg orally twice a day#N#-Maintenance dose: After a minimum of 2 weeks of treatment, if the initial dosage is well tolerated, it can be increased to 3 mg twice a day; subsequent increases to 4.5 mg and 6 mg twice a day should be attempted only after a minimum of 2 weeks at the previous dosage#N#TRANSDERMAL PATCH:#N#-Initial Dose: 4.6 mg/24 hour patch applied to the skin once daily#N#-Maintenance Dose: After a minimum of 4 weeks of treatment at the initial dose, and if well tolerated, the dose can be increased to 9.5 mg/24 hours for as long as this dose is beneficial; the dose can then be increased to 13.3 mg/24 hours#N#-Maximum Dose: 13.3 mg/24 hour patch applied to skin daily; higher doses confer no appreciable additional benefit, and are associated with significant increase in the incidence of adverse events#N#SEVERE ALZHEIMER'S DISEASE:#N#TRANSDERMAL PATCH:#N#-Recommended dose: 13.3 mg/24 hours transdermal patch applied to skin once daily; replace with a new patch every 24 hours#N#Use: For the treatment of mild, moderate, or severe dementia of the Alzheimer's type (AD)

How to measure liquid medicine?

Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device ( not a kitchen spoon). You may swallow the liquid medicine directly from the syringe or mix the medicine with a small glass of water, fruit juice, or soda. Stir and drink this mixture within 4 hours after mixing.

Is rivastigmine good for dementia?

Rivastigmine is used to treat mild to moderate dementia caused by Alzheimer's or Parkinson's disease. Rivastigmine is not a cure for Alzheimer's or Parkinson's disease. Rivastigmine may also be used for purposes not listed in this medication guide.

Can you take rivastigmine if you are allergic to it?

You should not take rivastigmine if you are allergic to rivastigmine or similar medicines, such as felbamate, meprobamate, or carisoprodol. You should not take oral rivastigmine if you have ever had severe redness, itching, or skin irritation caused by wearing a rivastigmine transdermal skin patch. Tell your doctor if you have ever had:

Can you change your dose of rivastigmine?

Rivastigmine doses are based on weight. Your dose needs may change if you gain or lose weight. If you need surgery, tell your surgeon you currently use this medicine. If you stop taking rivastigmine for any reason, do not restart the medicine without talking to your doctor first.

Can you wear a rivastigmine patch?

Do not wear a rivastigmine transdermal skin patch at the same time you are taking rivastigmine capsules or oral liquid. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Brand Names: Canada

APO-Rivastigmine; Auro-Rivastigmine; Exelon; JAMP Rivastigmine; MED-Rivastigmine; MYLAN-Rivastigmine; NOVO-Rivastigmine [DSC]; PMS-Rivastigmine; RATIO-Rivastigmine [DSC]; Rivastigmine Patch 10; Rivastigmine Patch 15; Rivastigmine Patch 5; SANDOZ Rivastigmine

What do I need to tell my doctor BEFORE I take this drug?

If you are allergic to this drug; any part of this drug; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.

What are some things I need to know or do while I take this drug?

Tell all of your health care providers that you take this drug. This includes your doctors, nurses, pharmacists, and dentists.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

How is this drug best taken?

Use this drug as ordered by your doctor. Read all information given to you. Follow all instructions closely.

General drug facts

If your symptoms or health problems do not get better or if they become worse, call your doctor.

What are the side effects of rivastigmine?

Check with your doctor immediately if any of the following side effects occur while taking rivastigmine: More common. Diarrhea. indigestion. loss of appetite. loss of strength. nausea and vomiting. weight loss.

Does rivastigmine need medical attention?

Side effects not requiring immediate medical attention. Some side effects of rivastigmine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine.

What are the side effects of rivastigmine?

Rivastigmine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: 1 nausea 2 vomiting 3 loss of appetite 4 heartburn or indigestion 5 stomach pain 6 weight loss 7 diarrhea 8 constipation 9 gas 10 weakness 11 dizziness 12 headache 13 extreme tiredness 14 lack of energy 15 tremor or worsening of tremor 16 increased sweating 17 difficulty falling asleep or staying asleep 18 confusion

Why is rivastigmine prescribed?

Rivastigmine is used to treat dementia (a brain disorder that affects the ability to remember, think clearly, communicate, and perform daily activities and may cause changes in mood and personality) in people with Alzheimer's disease (a brain disease that slowly destroys ...

How often should I take rivastigmine?

It is usually taken twice a day with meals in the morning and evening. Follow the directions on your prescription label carefully and ask your doctor or pharmacist to explain any part you do not understand. Take rivastigmine exactly as directed.

Can you swallow rivastigmine?

Always use the oral dosing syringe that comes with rivastigmine solution to measure your dose.Talk to your doctor or pharmacist if you have questions about how to measure your dose of rivastigmine solution. Rivastigmine oral solution may be swallowed directly from the syringe or mixed with a liquid before use.

Does rivastigmine help with Alzheimer's?

Rivastigmine may improve the ability to think and remember or slow the loss of these abilities but does not cure Alzheimer's disease or dementia in people with Parkinson's disease. Continue to take rivastigmine even if you feel well. Do not stop taking rivastig mine without talking to your doctor.

Can you get pregnant while taking rivastigmine?

tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking rivastigmine, call your doctor . if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking rivastigmine.

Can you take rivastigmine twice?

Do not take a double dose to make up for a missed one. If you miss taking rivastigmine for more than a few days, talk to your doctor before starting to take it again. You will probably have to restart taking it at a lower dose.

What are the symptoms of a swollen chest?

Chest pain or discomfort. increased sweating. increased watering of the mouth. irregular, fast, slow, or shallow breathing. lightheadedness, dizziness, or fainting. nausea (severe) pale or blue lips, fingernails, or skin. seizures. slow or irregular heartbeat.

Does vomiting go away with a med?

vomiting (severe) Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Can medicine cause side effects?

Side Effects. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur:

How many people have been treated with rivastigmine tartrate?

Rivastigmine tartrate has been administered to 779 individuals during clinical trials worldwide. Of these, 663 patients have been treated for at least 3 months, 476 patients have been treated for at least 6 months, and 313 patients have been treated for 1 year.

What are the most common adverse reactions to rivastigmine tartrate?

These include nausea, vomiting, anorexia, dyspepsia, and asthenia.

How long does rivastigmine inhibit cholinesterase?

After a 6 mg dose of Rivastigmine, anticholinesterase activity is present in cerebrospinal fluid (CSF) for about 10 hours, with a maximum inhibition of about 60% 5 hours after dosing.#N#In vitro and in vivo studies demonstrate that the inhibition of cholinesterase by Rivastigmine is not affected by the concomitant administration of memantine, an N-methyl-D-aspartate receptor antagonist.

How long does rivastigmine last?

Because strategies for the management of overdose are continually evolving, it is advisable to contact a Poison Control Center to determine the latest recommendations for the management of an overdose of any drug.#N#As Rivastigmine has a short plasma half-life of about 1 hour and a moderate duration of acetylcholinesterase inhibition of 8 to 10 hours, it is recommended that in cases of asymptomatic overdoses, no further dose of Rivastigmine tartrate should be administered for the next 24 hours.#N#As in any case of overdose, general supportive measures should be utilized.#N#Overdosage with cholinesterase inhibitors can result in cholinergic crisis characterized by severe nausea, vomiting, salivation, sweating, bradycardia, hypotension, respiratory depression, collapse and convulsions. Increasing muscle weakness is a possibility and may result in death if respiratory muscles are involved. Atypical responses in blood pressure and heart rate have been reported with other drugs that increase cholinergic activity when coadministered with quaternary anticholinergics such as glycopyrrolate. Additional symptoms associated with Rivastigmine overdose are diarrhea, abdominal pain, dizziness, tremor, headache, somnolence, confusional state, hyperhidrosis, hypertension, hallucinations and malaise. Due to the short half-life of Rivastigmine, dialysis (hemodialysis, peritoneal dialysis, or hemofiltration) would not be clinically indicated in the event of an overdose.#N#In overdoses accompanied by severe nausea and vomiting, the use of antiemetics should be considered. A fatal outcome has been rarely reported with Rivastigmine.

What is rivastigmine tartrate?

Rivastigmine tartrate is a reversible cholinesterase inhibitor and is known chemically as (S)-N-Ethyl-N-methyl-3- [1- (dimethylamino)ethyl]-phenyl carbamate hydrogen- (2R,3R)-tartrate. Rivastigmine tartrate is commonly referred to in the pharmacological literature as SDZ ENA 713 or ENA 713. It has a molecular formula of C 14 H 22 N 2 O 2 • C 4 H 6 O 6 (hydrogen tartrate salt–hta salt) and a molecular weight of 400.43 g/mol (hta salt). Rivastigmine tartrate USP is a white to off-white powder that is very soluble in water, soluble in ethanol and acetonitrile, slightly soluble in n-octanol and very slightly soluble in ethyl acetate.#N#The distribution coefficient at 37°C in n-octanol/phosphate buffer solution pH 7 is 3.0.

Does rivastigmine affect embryo development?

Oral administration of Rivastigmine to pregnant rats and rabbits throughout organogenesis produced no adverse effects on embryo-fetal development up to the highest dose tested (2.3 mg/kg/day), which is 2 and 4 times, respectively, the MRHD of 12 mg per day on a body surface area (mg/m 2) basis.

Is rivastigmine tartrate safe for pregnant women?

There are no adequate data on the developmental risks associated with the use of Rivastigmine tartrate in pregnant women. In animals, no adverse effects on embryo-fetal development were observed at oral doses 2 to 4 times the maximum recommended human dose (MRHD) (see Data).

What to do if you take rivastigmine patch?

This includes your doctors, nurses, pharmacists, and dentists. Avoid driving and doing other tasks or actions that call for you to be alert until you see how rivastigmine patch affects you. Talk with your doctor before you drink alcohol.

What are the side effects of a syringe?

Call your doctor right away if you have signs of dehydration like dry skin, mouth, or eyes; thirst; fast heartbeat; dizziness; fast breathing; or confusion.

Can you give a child rivastigmine?

If the patient is a child. Do not give rivastigmine patch to a child. This is not a list of all drugs or health problems that interact with rivastigmine patch. Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe ...

Can a drug cause side effects?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Upset stomach or throwing up. Not hungry.

Can you take rivastigmine before an MRI?

Your temperature may rise and cause too much drug to pass into your body. The patch may have metal. Take off the patch before an MRI. It is common to have diarrhea, loss of appetite, nausea, throwing up, or weight loss with rivastigmine patch.

Most voted positive review

I accidently gave my dad 12mg instead of 6mg a day I didn't realize it until after a month later Now I am giving him 6mg and he is complaining of headaches also very sleepy and not walking very good. His doctor will not return my phone calls untill after the week end. Is this normal response to the change of medication?

Most voted negative review

My mother took this medicine for only 3 days and had very bad diahrea, dehydrated, weakness, tired. She ended up in the hospital for 2 days!

Shared reviews and ratings

Everytime I have taken this medication, it has made me nauseous, vomit, dizzy, accelerated heartbeat, and paranoid.

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