2 hours ago · Common side effects of imipramine may include: increased blood pressure; tingly feeling, weakness, lack of coordination; dry mouth, nausea, vomiting; or. breast swelling (in men or women). This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. >> Go To The Portal
To make sure imipramine is safe for you, tell your doctor if you have: heart disease, a history of heart attack, stroke, or seizures; bipolar disorder (manic-depression), schizophrenia or other mental illness; kidney or liver disease;
Clinical studies of Imipramine Pamoate in the original application did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Post-marketing clinical experience has not identified differences in responses between the elderly and younger subjects.
An ECG recording should be taken prior to the initiation of larger-than-usual doses of Imipramine hydrochloride tablets, USP and at appropriate intervals thereafter until steady state is achieved. (Patients with any evidence of cardiovascular disease require cardiac surveillance at all dosage levels of the drug.
Imipramine is a tricyclic antidepressant. Imipramine affects chemicals in the brain that may be unbalanced in people with depression. Imipramine is used to treat symptoms of depression.
Imipramine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:nausea.drowsiness.weakness or tiredness.excitement or anxiety.nightmares.dry mouth.skin more sensitive to sunlight than usual.changes in appetite or weight.More items...•
Imipramine may be used to treat depression and nocturnal enuresis in children Label. Unlabeled indications include chronic and neuropathic pain (including diabetic neuropathy), panic disorder, attention-deficit/hyperactivity disorder (ADHD), and post-traumatic stress disorder (PTSD) 12,11,1,13,14,15,2.
This drug has a black box warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients about drug effects that may be dangerous. Imipramine may increase the risk of suicidal thoughts or actions in children, teenagers, and young adults.
In our experience orthostatic hypotension is the commonest serious cardiovascular side-effect of imipramine.
Imipramine caused a moderate increase in supine systolic blood pressure, and a pronounced increase in the rise in heart rate, when the subjects assumed erect position.
SymptomsAgitation or restlessness.Insomnia.Confusion.Rapid heart rate and high blood pressure.Dilated pupils.Loss of muscle coordination or twitching muscles.High blood pressure.Muscle rigidity.More items...•
Among the patients with cardiovascular disease, 4 developed congestive heart failure during imipramine administration, while severe postural hypotension was observed in 10 of 41 (24.4 per cent). Two developed myocardial infarction during a hypotensive period.
Adverse Effects The anticholinergic properties of imipramine can produce undesired side effects such as blurred vision, constipation, tachycardia, confusion, dry mouth, urinary retention, delirium, and narrow-angle glaucoma.
Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.
Cardiovascular: Orthostatic hypotension, hypertension, tachycardia, palpitation, myocardial infarction, arrhythmias, heart block, ECG changes, precipitation of congestive heart failure, stroke.
These results suggest that postural hypotension associated with antidepressant medication is caused in large part by a failure of reflex peripheral vasoconstriction.
Tricyclic antidepressants have been associated with increases in blood pressure, as well as orthostatic hypotension, particularly imipramine.
You should not use imipramine if you are allergic to it, or if: 1. you recently had a heart attack; or 2. you are allergic to other antidepressants...
Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use t...
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to...
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of imipramine can be fatal.Overdose symptoms may inclu...
Do not drink alcohol. Dangerous side effects or death can occur when alcohol is combined with imipramine. Check your food and medicine labels to be...
Taking this medicine with other drugs that make you sleepy can worsen this effect. Ask your doctor before taking imipramine with a sleeping pill, n...
Prescribers or other health professionals should inform patients, their families, and their caregivers about the benefits and risks associated with treatment with Imipramine hydrochloride and should counsel them in its appropriate use. A patient Medication Guide about “Antidepressant Medicines, Depression and other Serious Mental Illnesses, and Suicidal Thoughts or Actions” is available for Imipramine hydrochloride. The prescriber or health professional should instruct patients, their families, and their caregivers to read the Medication Guide and should assist them in understanding its contents. Patients should be given the opportunity to discuss the contents of the Medication Guide and to obtain answers to any questions they may have. The complete text of the Medication Guide is reprinted at the end of this document.
Note -In enuretic children treated with Imipramine hydrochloride the most common adverse reactions have been nervousness, sleep disorders, tiredness, and mild gastrointestinal disturbances. These usually disappear during continued drug administration or when dosage is decreased.
The pooled analyses of placebo-controlled trials in children and adolescents with MDD, obsessive compulsive disorder (OCD), or other psychiatric disorders included a total of 24 short-term trials of 9 antidepressant drugs in over 4400 patients. The pooled analyses of placebo-controlled trials in adults with MDD or other psychiatric disorders included a total of 295 short-term trials (median duration of 2 months) of 11 antidepressant drugs in over 77,000 patients. There was considerable variation in risk of suicidality among drugs, but a tendency toward an increase in the younger patients for almost all drugs studied. There were differences in absolute risk of suicidality across the different indications, with the highest incidence in MDD. The risk differences (drug vs. placebo), however, were relatively stable within age strata and across indications. These risk differences (drug-placebo difference in the number of cases of suicidality per 1000 patients treated) are provided in Table 1.
Patients of all ages who are started on antidepressant therapy should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber.
Imipramine hydrochloride is supplied in tablet form for oral administration.
Therefore, hospital monitoring is required as soon as possible. Children have been reported to be more sensitive than adults to an a cute overdosage of Imipramine hydrochloride. An acute overdose of any amount in infants or young children, especially, must be considered serious and potentially fatal.
Although a causal relationship between these effects and the drug could not be established, the possibility of fetal risk from the maternal ingestion of Imipramine hydrochloride cannot be excluded. Therefore, Imipramine hydrochloride should be used in women who are or might become pregnant only if the clinical condition clearly justifies potential risk to the fetus.
Make sure you tell your doctor if you have any other medical problems, especially: Bipolar disorder (mood disorder with mania and depression), or risk of or. Diabetes or. Glaucoma (angle-closure type), or. Heart or blood vessel disease or.
However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Uses for imipramine. Imipramine is used to treat depression. It belongs to a group of medicines known as tricyclic antidepressants (TCA). These medicines are thought to work by increasing the activity of a chemical called serotonin in the brain.
Appropriate studies have not been performed on the relationship of age to the effects of imipramine tablets in children with enuresis (bedwetting) younger than 6 years of age. Safety and efficacy have not been established.
Thioridazine. Tranylcypromine. Ziprasidone. Using imipramine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies or colds, sedatives, tranquilizers, or sleeping medicines, prescription pain medicine or narcotics, medicine for seizures or barbiturates, muscle relaxants, or anesthetics, including some dental anesthetics.
Appropriate studies have not been performed on the relationship of age to the effects of imipramine capsules to treat depression in the pediatric population. Safety and efficacy have not been established.
Information for Patients. Prescribers or other health professionals should inform patients, their families, and their caregivers about the benefits and risks associated with treatment with Imipramine Pamoate and should counsel them in its appropriate use.
Oral: Imipramine Pamoate was fed to male and female albino rats for 28 weeks through two breeding cycles at dose levels of 15 mg/kg/day and 40 mg/kg/day (equivalent to 2 1/2 and 7 times the maximum human dose). No abnormalities which could be related to drug administration were noted in gross inspection.
The pooled analyses of placebo-controlled trials in children and adolescents with MDD, obsessive compulsive disorder (OCD), or other psychiatric disorders included a total of 24 short-term trials of 9 antidepressant drugs in over 4400 patients. The pooled analyses of placebo-controlled trials in adults with MDD or other psychiatric disorders included a total of 295 short-term trials (median duration of 2 months) of 11 antidepressant drugs in over 77,000 patients. There was considerable variation in risk of suicidality among drugs, but a tendency toward an increase in the younger patients for almost all drugs studied. There were differences in absolute risk of suicidality across the different indications, with the highest incidence in MDD. The risk differences (drug vs placebo), however, were relatively stable within age strata and across indications. These risk differences (drug-placebo difference in the number of cases of suicidality per 1000 patients treated) are provided in Table 1.
The drugs that inhibit cytochrome P450 2D6 include some that are not metabolized by the enzyme (quinidine; cimetidine) and many that are substrates for P450 2D6 (many other antidepressants, phenothiazines, and the Type 1C antiarrhythmics propafenone and flecainide). While all the selective serotonin reuptake inhibitors (SSRIs), e.g., fluoxetine, sertraline, and paroxetine, inhibit P450 2D6, they may vary in the extent of inhibition. The extent to which SSRI-TCA interactions may pose clinical problems will depend on the degree of inhibition and the pharmacokinetics of the SSRI involved. Nevertheless, caution is indicated in the co-administration of TCAs with any of the SSRIs and also in switching from one class to the other. Of particular importance, sufficient time must elapse before initiating TCA treatment in a patient being withdrawn from fluoxetine, given the long half-life of the parent and active metabolite (at least 5 weeks may be necessary).
Critical manifestations of overdose include cardiac dysrhythmias, severe hypotension, convulsions, and CNS depression including coma. Changes in the electrocardiogram, particularly in QRS axis or width, are clinically significant indicators of tricyclic toxicity.
Patients of all ages who are started on antidepressant therapy should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber.
The following symptoms, anxiety, agitation, panic attacks, insomnia, irritability, hostility, aggressiveness, impulsivity, akathisia (psychomotor restlessness), hypomania, and mania, have been reported in adult and pediatric patients being treated with antidepressants for major depressive disorder as well as for other indications, both psychiatric and nonpsychiatric. Although a causal link between the emergence of such symptoms and either the worsening of depression and/or the emergence of suicidal impulses has not been established, there is concern that such symptoms may represent precursors to emerging suicidality.
You should not stop using imipramine suddenly. Follow your doctor's instructions about tapering your dose. Store at room temperature away from moisture, heat, and light.
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Imipramine is a tricyclic antidepressant used to treat symptoms of depression. Imipramine is sometimes used to treat bed-wetting in children ages 6 and older.
Some young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.
Tell your doctor if you have used an "SSRI" antidepressant in the past 5 weeks, such as citalopram, escitalopram, fluoxetine ( Prozac ), fluvoxamine, paroxetine, sertraline ( Zoloft ), trazodone, or vilazodone. problems with urination. Some young people have thoughts about suicide when first taking an antidepressant.
Common side effects may include: increased blood pressure; tingly feeling, weakness, lack of coordination; dry mouth, nausea, vomiting; or. breast swelling (in men or women). This is not a complete list of side effects and others may occur.
Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.