18 hours ago · Side effects requiring immediate medical attention Abdominal or stomach pain agitation blurred vision burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings chest pain or discomfort clay-colored stools cold sweats confusion about identity, place, and time ... >> Go To The Portal
Side effects requiring immediate medical attention
Imipramine Side Effects 1 Incidence Not Known. 2 Symptoms of Overdose. Some side effects of imipramine may occur that usually do not need medical... 3 General. The most commonly reported side effects were tremors, increased weight, dry mouth,... 4 Hypersensitivity. 5 Psychiatric. 6 ... (more items)
talk to your doctor about the risks and benefits of taking imipramine if you are 65 years of age or older. Older adults should not usually take imipramine because it is not as safe and effective as other medications that can be used to treat the same condition.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of imipramine in the elderly. However, elderly patients are more likely to have age-related kidney, liver, or heart problems, which may require caution and an adjustment in the dose for patients receiving imipramine.
If you do take them together or do not wait 2 weeks, you may develop confusion, agitation, restlessness, stomach or intestinal symptoms, a sudden high body temperature, an extremely high blood pressure, or severe convulsions. Imipramine may cause some teenagers and young adults to be agitated, irritable, or display other abnormal behaviors.
This drug has a black box warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients about drug effects that may be dangerous. Imipramine may increase the risk of suicidal thoughts or actions in children, teenagers, and young adults.
Adverse Effects The anticholinergic properties of imipramine can produce undesired side effects such as blurred vision, constipation, tachycardia, confusion, dry mouth, urinary retention, delirium, and narrow-angle glaucoma.
Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.
Imipramine withdrawal symptoms include nausea, headache, fatigue, general malaise, lack of coordination, crying spells, depersonalization, flu-like symptoms, overreacting as well as sensory or sleep disturbances.
Imipramine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:nausea.drowsiness.weakness or tiredness.excitement or anxiety.nightmares.dry mouth.skin more sensitive to sunlight than usual.changes in appetite or weight.More items...•
In our experience orthostatic hypotension is the commonest serious cardiovascular side-effect of imipramine.
Imipramine caused a moderate increase in supine systolic blood pressure, and a pronounced increase in the rise in heart rate, when the subjects assumed erect position.
Anticholinergic: Dry mouth, and, rarely, associated sublingual adenitis; blurred vision, disturbances of accommodation, mydriasis; constipation, paralytic ileus; urinary retention, delayed micturition, dilation of the urinary tract.
Tell your doctor right away if you have any serious side effects, including: mental/mood changes (such as confusion, depression, memory problems), enlarged/painful breasts, unusual breast milk production, irregular/painful menstrual periods, muscle stiffness, restlessness, ringing in the ears, sexual problems (such as ...
Tricyclic antidepressants (TCAs)dry mouth.slight blurring of vision.constipation.problems passing urine.drowsiness.dizziness.weight gain.excessive sweating (especially at night)More items...
Imipramine may cause a serious condition called serotonin syndrome if taken together with some medicines. Do not use imipramine with buspirone (Buspar®), fentanyl (Abstral®, Duragesic®), lithium (Eskalith®, Lithobid®), methylene blue injection, tryptophan, St.
Serotonin syndrome is a serious drug reaction. It is caused by medications that build up high levels of serotonin in the body. Serotonin is a chemical that the body produces naturally. It's needed for the nerve cells and brain to function.
Acetylcholine: imipramine is an anticholinergic, specifically an antagonist of the muscarinic acetylcholine receptors.
ClassDrugsRelative anticholinergic potencyPsychotropicSelective serotonin reuptake inhibitor (SSRI) antidepressants: citalopram, fluoxetine, fluvoxamine, paroxetine*LowTricyclic antidepressants: amitriptyline, clomipramine, desipramine, doxepin, imipramine, nortriptyline, othersHigh21 more rows
Anticholinergics are drugs that block the action of acetylcholine ....Examples of these drugs include:atropine (Atropen)belladonna alkaloids.benztropine mesylate (Cogentin)clidinium.cyclopentolate (Cyclogyl)darifenacin (Enablex)dicylomine.fesoterodine (Toviaz)More items...
A few examples of anticholinergic drugs are antidepressants like Paxil (paroxetine), Thorazine (chlorpromazine), and Clozaril (clozapine).
lack of coordination. lethargy. loss of balance control. lower back or side pain. mood or mental changes. muscle spasm or jerking of all extremities. muscle trembling, jerking, or stiffness. nightmares. pain or discomfort in the arms, jaw, back, or neck.
Side Effects. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur:
Make sure you tell your doctor if you have any other medical problems, especially: Bipolar disorder (mood disorder with mania and depression), or risk of or. Diabetes or. Glaucoma (angle-closure type), or. Heart or blood vessel disease or.
However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Uses for imipramine. Imipramine is used to treat depression. It belongs to a group of medicines known as tricyclic antidepressants (TCA). These medicines are thought to work by increasing the activity of a chemical called serotonin in the brain.
Children—Use and dose must be determined by your doctor. For enuresis (bedwetting): Children 6 years of age and older—At first, 25 milligrams (mg) once a day, taken 1 hour before bedtime. Your doctor may adjust the dose as needed.
Thioridazine. Tranylcypromine. Ziprasidone. Using imipramine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
For oral dosage form (capsules): For depression: Adults—At first, 75 milligrams (mg) once a day.
Families and caregivers should be advised of the need for close observation and communication with the prescriber. Imipramine pamoate is not approved for use in pediatric patients . Medically reviewed by Drugs.com.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088 . Medically Reviewed on 10/9/2020.
The drugs that inhibit cytochrome P450 2D6 include some that are not metabolized by the enzyme (quinidine; cimetidine) and many that are substrates for P450 2D6 (many other antidepressants, phenothiazines, and the Type 1C antiarrhythmics propafenone and flecainide).
Concurrent use of cimetidine can increase Tofranil blood levels by reducing elimination of Tofranil from the body and possibly lead to Tofranil-related side effects. Other drugs which share this effect include propafenone, flecainide, quinidine, methylphenidate, and fluoxetine.
Drug interactions of Tofranil include other medications and drugs that slow the brain's processes , such as alcohol, barbiturates, benzodiazepines, zolpidem, and narcotics, which may add to the effect of Tofranil on the brain. Reserpine, given to patients taking TCAs, can cause agitation and anxiety.
Depending on the fraction of drug metabolized by P450 2D6, the increase in plasma concentration may be small, or quite large (8-fold increase in plasma AUC of the TCA).
Imipramine also can cause elevated pressure in the eyes of some patients with glaucoma. Following prolonged therapy with high doses, abrupt discontinuation of TCAs, including imipramine, could lead to withdrawal symptoms such as. nausea, vomiting, diarrhea, or. restlessness.
These neurotransmitters are chemicals that the nerves in the brain use to communicate with each other. Tofranil is believed to elevate mood by raising the levels of neurotransmitters in the brain. Common side effects of Tofranil include. nausea, vomiting, weakness, confusion, anxiety, insomnia,
If you stop taking imipramine, you should wait at least 14 days before you start to take an MAO inhibitor. tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take.
When imipramine tablets or capsules are used to treat depression, they are usually taken one or more times a day and may be taken with or without food. When imipramine tablets are used to prevent bedwetting in children, they are usually taken one hour before bedtime.
tell your doctor and pharmacist if you are allergic to imipramine, any other medications, or any of the ingredients in imipramine tablets or capsules. Ask your doctor or pharmacist for a list of the ingredients.
It may take 1-3 weeks or longer for you to feel the full benefit of imipramine. Continue to take imipramine even if you feel well. Do not stop taking imipramine without talking to your doctor. Your doctor will probably want to decrease your dose gradually.
Expand Section. Imipramine tablets and capsules are used to treat depression. Imipramine tablets are also used to prevent bedwetting in children . Imipramine is in a class of medications called tricyclic antidepressants.
Expand Section. Imipramine is also used occasionally to treat eating disorders and panic disorders. Talk to your doctor about the possible risks of using this medication for your condition. This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.
A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants ('mood elevators') such as imipramine during clinical studies became suicidal (thinking about harming or killing oneself or planning or trying to do so). Children, teenagers, and young adults who take antidepressants to treat depression or other mental illnesses may be more likely to become suicidal than children, teenagers, and young adults who do not take antidepressants to treat these conditions. However, experts are not sure about how great this risk is and how much it should be considered in deciding whether a child or teenager should take an antidepressant. Children younger than 18 years of age should not normally take imipramine except to prevent bedwetting, but in some cases, a doctor may decide that imipramine is the best medication to treat a child's condition.
You should not stop using imipramine suddenly. Follow your doctor's instructions about tapering your dose. Store at room temperature away from moisture, heat, and light.
Imipramine is a tricyclic antidepressant used to treat symptoms of depression. Imipramine is sometimes used to treat bed-wetting in children ages 6 and older. Imipramine may also be used for purposes not listed in this medication guide.
Tell your doctor if you have used an "SSRI" antidepressant in the past 5 weeks, such as citalopram, escitalopram, fluoxetine ( Prozac ), fluvoxamine, paroxetine, sertraline ( Zoloft ), trazodone, or vilazodone. problems with urination. Some young people have thoughts about suicide when first taking an antidepressant.
Common side effects may include: increased blood pressure; tingly feeling, weakness, lack of coordination; dry mouth, nausea, vomiting; or. breast swelling (in men or women). This is not a complete list of side effects and others may occur.
Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.
Do not use imipramine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, tranylcypromine, and others.
Do not drink alcohol. Dangerous side effects or death can occur when alcohol is combined with imipramine. Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired. Avoid exposure to sunlight or tanning beds. Imipramine can make you sunburn more easily.