new adnexal masses in a patient with a history of chronic myelogenous leukemia : a case report

by Marcos Barton 6 min read

New adnexal masses in a patient with a history of …

2 hours ago presented with rapidly developing adnexal masses. Case Presentation A 31 year old African-American female with a personal history of CML diagnosed at age 17 presented to the … >> Go To The Portal


How long does it take to develop chronic myeloid leukemia (CML)?

The time between initial diagnosis of ET and transformation to CML was six, 12, 13, nine, and 18 years, respectively. Our case had a history that covered a period of seven years. On the emergence of CML, previously reported cases used treatment with imatinib mesylate (in four cases) and interferon-alpha (in one case).

Can chronic myelogenous leukemia (CML) co-occur with BCR-ABL-negative chronic MPDS?

Few clinical cases have reported the progression of ET to chronic myelogenous leukemia (CML) with the expression of the BCR-ABL gene. This report describes such a case and includes a review of other reported cases of CML co-occurring with BCR-ABL-negative chronic MPDs.

What are the diagnostic guidelines for chronic myelogenous leukemia (CML)?

According to the current guidelines from the World Health Organization (WHO), BCR-ABL1 gene positivity is diagnostic for chronic myelogenous leukemia (CML). BCR-ABL1-negative MPNs include PV, ET, and PMF.

Background

Chronic myeloproliferative disorders (MPDs) include polycythemia vera (PV), primary myelofibrosis (PMF), and essential thrombocythemia (ET) [ 1 ]. According to the current guidelines from the World Health Organization (WHO), BCR-ABL1 gene positivity is diagnostic for chronic myelogenous leukemia (CML).

References

1. Tefferi A, Thiele J, Vardiman JW. The 2008 World Health Organization classification system for myeloproliferative neoplasms: Order out of chaos. Cancer. 2009;115(17):3842–47. [ PubMed] [ Google Scholar]