16 hours ago presented with rapidly developing adnexal masses. Case Presentation A 31 year old African-American female with a personal history of CML diagnosed at age 17 presented to the … >> Go To The Portal
The time between initial diagnosis of ET and transformation to CML was six, 12, 13, nine, and 18 years, respectively. Our case had a history that covered a period of seven years. On the emergence of CML, previously reported cases used treatment with imatinib mesylate (in four cases) and interferon-alpha (in one case).
Few clinical cases have reported the progression of ET to chronic myelogenous leukemia (CML) with the expression of the BCR-ABL gene. This report describes such a case and includes a review of other reported cases of CML co-occurring with BCR-ABL-negative chronic MPDs.
According to the current guidelines from the World Health Organization (WHO), BCR-ABL1 gene positivity is diagnostic for chronic myelogenous leukemia (CML). BCR-ABL1-negative MPNs include PV, ET, and PMF.
Chronic myeloproliferative disorders (MPDs) include polycythemia vera (PV), primary myelofibrosis (PMF), and essential thrombocythemia (ET) [ 1 ]. According to the current guidelines from the World Health Organization (WHO), BCR-ABL1 gene positivity is diagnostic for chronic myelogenous leukemia (CML).
1. Tefferi A, Thiele J, Vardiman JW. The 2008 World Health Organization classification system for myeloproliferative neoplasms: Order out of chaos. Cancer. 2009;115(17):3842–47. [ PubMed] [ Google Scholar]