2 hours ago · Generic name: losartan [ loe-SAR-tan ] Brand name: Cozaar Drug class: Angiotensin receptor blockers. Medically reviewed by Sanjai Sinha, MD. Last updated on Sep 30, 2021. Uses; Warnings; Before taking; Dosage; Side effects; Interactions; FAQ; What is losartan? Losartan belongs to a group of drugs called angiotensin II receptor antagonists. It keeps blood … >> Go To The Portal
Generic name: losartan (loe SAR tan) Brand name: Cozaar Drug class: Angiotensin receptor blockers
1 Use losartan in LIFE-THREATNING emergencies when no safer drug is available. 2 Use of losartan or other drugs that act on the renin-angiotensin system during... 3 When pregnancy is detected, discontinue of losartan as soon as possible. 4 It is unknown if losartan is excreted in milk; therefore use of losartan is not recommended...
Clinical Studies 1 14.1 Hypertension. The antihypertensive effects of Losartan potassium were demonstrated principally in 4 placebo-controlled, 6-to 12-week trials of dosages from 10 to 150 mg per day in patients with baseline ... 2 14.2 Hypertensive Patients with Left Ventricular Hypertrophy. ... 3 14.3 Nephropathy in Type 2 Diabetic Patients. ...
Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine. If you have diabetes, do not use losartan together with any medication that contains aliskiren (Amturnide, Tekturna, Tekamlo, Valturna).
Reevaluate blood pressure (including orthostatic blood pressure), renal function, and serum potassium. Patients with systolic blood pressure <80 mm Hg, low serum sodium, diabetes mellitus, and impaired renal function should be closely monitored (ACC/AHA).
Losartan (Cozaar) is available as a generic medication and may be significantly cheaper compared to the brand version. Unless there is a specific reason you need the brand, the generic medication will be a better value.
Losartan belongs to a class of drugs called angiotensin receptor blockers (ARBs). It works by relaxing blood vessels so that blood can flow more easily.
Dosage to reduce stroke risk in people with high blood pressure and left ventricular hypertrophy. The typical dosage is 50 mg taken once daily. Your doctor may increase your dosage to 100 mg per day if needed. You may take losartan once or twice per day.
Losartan: a medicine to treat high blood pressure - NHS.
Official Answer. Losartan and Losartan Potassium are the same thing. Losartan Potassium is the full name including the salt (potassium). Both will deliver the stated amount of losartan.
Lisinopril and losartan basically do the same thing — but in different ways. Lisinopril belongs to the classification of drugs called ACE (angiotensin-converting enzyme) inhibitors, while losartan is in the ARB (angiotensin II receptor-blocker) class.
Is losartan an ACE inhibitor or a beta blocker? Losartan is an angiotensin receptor blocker. It is not an ACE inhibitor or a beta blocker.
Common losartan side effects may include:cold or flu symptoms such as stuffy nose, sneezing, sore throat, fever;dry cough;muscle cramps;pain in your legs or back;stomach pain, diarrhea;headache, dizziness;tired feeling; or.sleep problems (insomnia).
Take losartan tablets once a day. Your doctor may suggest that you take your first dose before bedtime, because it can make you feel dizzy. After your first dose, you can take losartan at any time of day. But try to take it at the same time every day.
Why were these products recalled? Losartan was recalled due to impurities found while testing finished products. The impurity found in these batches is N-Methylnitrosobutyric acid (NMBA). This is the third type of impurity to cause recalls of these medications.
Potassium supplements, potassium-containing salt substitutes (No Salt, Morton Salt Substitute, and others), and even high-potassium foods (including Noni juice) should be avoided by those taking losartan, unless directed otherwise by their doctor.
There is a risk of acute kidney failure developing in people taking losartan.
Losartan causes weight fat loss by reducing blood cholesterol levels. More specifically, it lowers the amount of bad cholesterol and triglyceride circulating in the blood and fat deposits in the adipose tissue.
You should not use losartan if you are allergic to it.If you have diabetes, do not use losartan together with any medication that contains aliskire...
Take losartan exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose...
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to...
Usual Adult Dose of Losartan for Diabetic Nephropathy:Initial dose: 50 mg orally once a day.Maintenance dose: 25 to 100 mg orally in 1 to 2 divided...
Tell your doctor about all medicines you use, and those you start or stop using during your treatment with losartan, especially: 1. a diuretic or "...
It depends. In some people (such as those with existing kidney issues), losartan (Cozaar) can affects how well the kidney works. For people with di...
It takes about 6 hours for losartan (Cozaar) to start lowering your blood pressure, but it may take several weeks before it reaches its full effect.
Acetaminophen (Tylenol) is generally safe to take with losartan (Cozaar). Talk to your doctor or pharmacist before taking losartan (Cozaar) with NS...
Yes, losartan (Cozaar) can be taken with or without food.
No, losartan (Cozaar) is not a diuretic or "water pill" so it shouldn't make you urinate more than normal.
The LIFE study was a multinational, double-blind study comparing Losartan potassium and atenolol in 9193 hypertensive patients with ECG-documented left ventricular hypertrophy. Patients with myocardial infarction or stroke within six months prior to randomization were excluded. Patients were randomized to receive once daily Losartan potassium 50 mg or atenolol 50 mg. If goal blood pressure (<140/90 mmHg) was not reached, hydrochlorothiazide (12.5 mg) was added first and, if needed, the dose of Losartan potassium or atenolol was then increased to 100 mg once daily. If necessary, other antihypertensive treatments (e.g., increase in dose of hydrochlorothiazide therapy to 25 mg or addition of other diuretic therapy, calcium-channel blockers, alpha-blockers, or centrally acting agents, but not ACE inhibitors, angiotensin II antagonists, or beta-blockers) were added to the treatment regimen to reach the goal blood pressure.
Losartan is an orally active agent that undergoes substantial first-pass metabolism by cytochrome P450 enzymes. It is converted, in part, to an active carboxylic acid metabolite that is responsible for most of the angiotensin II receptor antagonism that follows Losartan treatment. About 14% of an orally-administered dose of Losartan is converted to the active metabolite. In addition to the active carboxylic acid metabolite, several inactive metabolites are formed. In vitro studies indicate that cytochrome P450 2C9 and 3A4 are involved in the biotransformation of Losartan to its metabolites.
Angiotensin II [formed from angiotensin I in a reaction catalyzed by angiotensin converting enzyme (ACE, kininase II)] is a potent vasoconstrictor , the primary vasoactive hormone of the renin-angiotensin system, and an important component in the pathophysiology of hypertension. It also stimulates aldosterone secretion by the adrenal cortex. Losartan and its principal active metabolite block the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT 1 receptor found in many tissues, (e.g., vascular smooth muscle, adrenal gland). There is also an AT 2 receptor found in many tissues but it is not known to be associated with cardiovascular homeostasis. Neither Losartan nor its principal active metabolite exhibits any partial agonist activity at the AT 1 receptor, and both have much greater affinity (about 1000-fold) for the AT 1 receptor than for the AT 2 receptor. In vitro binding studies indicate that Losartan is a reversible, competitive inhibitor of the AT 1 receptor. The active metabolite is 10 to 40 times more potent by weight than Losartan and appears to be a reversible, non-competitive inhibitor of the AT 1 receptor.
Losartan potassium tablets are indicated for the treatment of hypertension in adults and pediatric patients 6 years of age and older, to lower blood pressure. Lowering blood pressure lowers the risk of fatal and nonfatal cardiovascular (CV) events, primarily strokes and myocardial infarction.
Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. When pregnancy is detected, discontinue Losartan potassium as soon as possible [see Use in Specific Populations ( 8.1 )].
Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. When pregnancy is detected, discontinue Losartan as soon as possible. These adverse outcomes are usually associated with use of these drugs in the second and third trimester of pregnancy.
to slow the worsening of diabetic kidney disease (nephropathy) in patients with type 2 diabetes who have or had high blood pressure. Losartan potassium tablets have not been studied in children less than 6 years old or in children with certain kidney problems. High Blood Pressure (hypertension).
Losartan is also used to decrease the risk of stroke in patients with high blood pressure and enlargement of the heart. It is also used to treat kidney problems in patients with type 2 diabetes and a history of hypertension. This medicine is available only with your doctor's prescription.
This can damage the blood vessels of the brain , heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. Lowering blood pressure may reduce the risk of strokes and heart attacks. Losartan is an angiotensin II receptor blocker (ARB).
As a result, losartan relaxes the blood vessels. A lower blood pressure will increase the supply of the blood and oxygen to the heart. Losartan is also used to decrease the risk of stroke in patients with high blood pressure and enlargement of the heart.
Losartan (Cozaar) is available as a generic medication and may be significantly cheaper compared to the brand version. Unless there is a specific reason you need the brand, the generic medication will be a better value. For even more savings, use a GoodRx coupon and pay just a fraction of the retail price.
Losartan (Cozaar) lowers your blood pressure and can make you feel lightheaded or dizzy. This is more likely if you're also taking other medications that lower your BP such as diuretics (water pills). This should go away after a few days, but talk to your doctor if it doesn't.
feeling of constant movement of self or surroundings. feeling sad or empty. headache, severe and throbbing. hearing loss. inability to have or keep an erection. increased sensitivity of the skin to sunlight. irritability. lack of appetite. loss in sexual ability, desire, drive, or performance.
large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue. Some side effects may occur that usually do not need medical attention.
Losartan (Cozaar): Basics, Side Effects & Reviews. Are you looking for information on Hyzaar (losartan/hctz) instead? Losartan (Cozaar) is a medication used to lower blood pressure. It can also help protect the kidneys, so it is a good first-line option for people with both hypertension and diabetes.
large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue. Some side effects may occur that usually do not need medical attention.
Acetaminophen (Tylenol) is generally safe to take with losartan (Cozaar). Talk to your doctor or pharmacist before taking losartan (Cozaar) with NSAIDs, such as ibuprofen (Advil) and naproxen (Aleve) — this combination can cause harm to your kidneys if you have kidney issues, are older, or are taking diuretics (water pills).
Losartan belongs to a class of drugs called angiotensin receptor blockers (ARBs). It works by relaxing blood vessels so that blood can flow more easily. Losartan is available under the following different brand names: Cozaar.
Losartan has moderate interactions with at least 156 different drugs. Losartan has minor interactions with at least 29 different drugs.
Discontinue as soon as possible when pregnancy is detected; drug affects renin- angiotensin system, causing oligohydramnios, which may result in fetal injury or death. This medication contains losartan. Do not take Cozaar if you are allergic to losartan or any ingredients contained in this drug. Keep out of reach of children.
Resulting levels of low amniotic fluid can be associated with fetal lung underdevelopment and skeletal deformations. Potential neonatal adverse effects include skull underdevelopment, failure of the kidneys to produce urine, low blood pressure, kidney failure, and death.
There is positive evidence of human fetal risk. Use of losartan or other drugs that act on the renin-angiotensin system during the 2nd and 3rd trimesters of pregnancy reduces renal function and increases fetal and neonatal morbidity and death.
Other side effects of Losartan include: ECG alterations: heart beat irregularities; prolongation of PR, QRS, and QT intervals. involuntary intermittent or sustained deviation of the eyes, appearing alone, as well as with other dystonic reactions; transient dizziness during or shortly after intravenous infusion.
The terminal elimination half lives of losartan and EXP3174 are about 1.5 to 2.5 hours and 3 to 9 hours, respectively.
Peak plasma concentrations of losartan and EXP3174 occur about one hour and three to four hours, respectively, after an oral dose. Both losartan and EXP3174 are more than 98% bound to plasma proteins. Losartan is excreted in the urine, and in the feces via bile, as unchanged drug and metabolites.
Losartan is well absorbed following oral administration and undergoes significant first-pass metabolism to produce the 5- carboxylic acid metabolite, designated as EXP3174. About 14% of an oral dosage is converted to this metabolite, which is long-acting (6 to 8 hr) and a noncompetitive antagonist at the AT 1 receptor, contributing to the pharmacological effects of losartan. EXP3174 is 10-40 times more potent in blocking AT 1 receptors than losartan. In addition, the binding to the target enzyme is pH-sensitive, and the negatively-charged tetrazole ring, which is similar in size to the negative carboxylic acid derivative, may contribute to the activity of the drug.
Losartan is used for hypertension, including in people with left ventricular hypertrophy (enlarged heart muscle), and kidney dysfunction among type II diabetics. It may also delay progression of diabetic nephropathy.
Between November 2018, and September 2019, the FDA announced multiple recalls of tablets containing losartan by Sandoz, Torrent Pharmaceuticals, Hetero Labs, Camber Pharmaceuticals, Legacy Pharmaceutical Packaging, Teva Pharmaceuticals, Vivimed Life Sciences, and Macleods Pharmaceutical Limited due to detection of one of the possible carcinogens N-nitrosodiethylamine, N-methylnitrosobutyric acid, or N-nitroso-N-methyl-4-aminobutyric acid in the active pharmaceutical ingredient (API).
Losartan. Losartan, sold under the trade name Cozaar among others, is a medication mainly used to treat high blood pressure. It is also used for diabetic kidney disease, heart failure, and left ventricular enlargement. It is taken by mouth. It may be used alone or in addition to other blood pressure medication.
Losartan administration results in a decrease in total peripher al resistance (afterload) and cardiac venous return (preload). All of the physiological effects of angiotensin II, including release of aldosterone, are antagonized in the presence of losartan.
IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional.
This drug can cause serious (possibly fatal) harm to an unborn baby if used during pregnancy. It is important to prevent pregnancy while taking this medication. Consult your doctor for more details and to discuss the use of reliable forms of birth control while taking this medication.
Losartan is used to treat high blood pressure (hypertension) and to help protect the kidneys from damage due to diabetes. It is also used to lower the risk of strokes in patients with high blood pressure and an enlarged heart. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems.
This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.This drug may also be used for heart failure.
Read the Patient Information Leaflet if available from your pharmacist before you start taking losartan and each time you get a refill. If you have any questions, ask your doctor or pharmacist.Take this medication by mouth as directed by your doctor, usually once daily with or without food.
Dizziness or lightheadedness may occur as your body adjusts to the medication.
Before taking losartan, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems.