Methods. We included adults from the Get With the Guidelines ® - Resuscitation registry with an in-hospital cardiac arrest. We used two a priori definitions for vital signs: abnormal (heart rate (HR) ≤ 60 or ≥ 100 min −1, respiratory rate (RR) ≤ 10 or > 20 min −1 and systolic blood pressure (SBP) ≤ 90 mm Hg) and severely abnormal (HR ≤ 50 or ≥ 130 min −1, RR ≤ 8 or ≥ 30 ....