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Advise patients and caregivers that the patient should stop taking CONTRAVE and contact a healthcare provider immediately if agitation, depressed mood, or changes in behavior or thinking that are not typical for the patient are observed, or if the patient develops suicidal ideation or suicidal behavior.
Nearly half of patients taking CONTRAVE lost 5% or more body weight and kept it off (vs 23% of patients taking placebo). ‡ Individual results may vary. ‡ According to 3 multicenter, double-blind, placebo-controlled obesity trials (BMI ≥30 kg/m 2, or BMI ≥27 kg/m 2 with at least 1 comorbidity of hypertension, dyslipidemia, or type 2 diabetes) conducted to evaluate the effect of …
For cash-paying patients with federal, state, or government-funded insurance who use the CONTRAVE Savings Card to purchase CONTRAVE as a cash-paying customer: (i) you confirm that your prescription for CONTRAVE is not covered by your insurance benefit; (ii) you are eligible to obtain CONTRAVE as a cash-paying patient for the remainder of the ...
There is a real weight-loss struggle that happens to many of us—and it’s not due to lack of commitment or effort. Through science, we can better understand this challenge because it turns out your brain may be working against you by sending hunger signals or triggering cravings, even when you’re not hungry.
Nearly half of patients taking CONTRAVE lost 5% or more body weight and kept it off (vs 23% of patients taking placebo). ‡ Individual results may vary.
The most common side effects of CONTRAVE includenausea, constipation, headache, vomiting, dizziness, trouble sleeping, dry mouth, and diarrhea. These are not all of the possible side effects of CONTRAVE. You are encouraged to report negative side effects of prescription drugs to the FDA.
Visual problems (angle-closure glaucoma). Signs and symptoms may include: eye pain, changes in vision, swelling or redness in or around the eye. Talk with your healthcare provider to find out if you are at risk for angle‐closure glaucoma and to get treatment to prevent it if you are at risk.
The risk of seizure is higher in people who take higher doses of CONTRAVE, have certain medical conditions, or take CONTRAVE with certain other medicines. Do not take any other medicines while you are taking CONTRAVE unless your healthcare provider has said it is okay to take them.
Everyday Offers Opportunities to Make Healthy Choices 1 Make a menu for breakfast, lunch, and dinner 2 Incorporate snacks into your meal plan throughout the day so you don’t get too hungry between meals 3 Make sure you’re getting enough fruits and vegetables
Make healthier choices, such as chicken, fish, or lean steak. Check product labels to make sure you’re meeting your nutritional needs, and see if you can swap them for a similar product with less sugar or fat. Don’t shop when you’re hungry—it can sway you from making healthy decisions.
Work to get 8 hours of sleep per night for optimal health and continued success. Manage Stress. Create distractions, focus your mind on something else, or even start a hobby. Keep a daily journal—this is a great way to help people stay on track and easily make diet and exercise adjustments when necessary.
The CONTRAVE Savings Coupon Card cannot be used if you are currently a Medicaid Beneficiary. Medicare Part D and TRICARE beneficiaries are eligible for the CONTRAVE Savings Coupon Card. However, to receive the CONTRAVE Savings Coupon Card benefits, your prescription will be processed with the assumption that you are a cash-paying customer.
Risk of opioid overdose. One of the ingredients in CONTRAVE ( naltrexone) can increase your chance of having an opioid overdose if you take opioid medicines while taking CONTRAVE. You can accidentally overdose in 2 ways: Naltrexone blocks the effects of opioids, such as heroin, or opioid pain medicines.
Naltrexone blocks the effects of opioids, such as heroin, or opioid pain medicines. Do not take large amounts of opioids, including opioid-containing medicines, such as heroin or prescription pain pills, to try to overcome the opioid-blocking effects of naltrexone. This can lead to serious injury, coma, or death.
Visual problems (angle-closure glaucoma). One of the ingredients in CONTRAVE, bupropion, can cause some people to have visual problems (angle-closure glaucoma). Signs and symptoms of angle-closure glaucoma may include: eye pain.
If over-exposure occurs, call your poison control center at 1-800-222-1222. There are no known antidotes for Contrave. In case of an overdose, provide supportive care, including close medical supervision and monitoring. Consider the possibility of multiple drug overdose. Ensure an adequate airway, oxygenation, and ventilation. Monitor cardiac rhythm and vital signs. Induction of emesis is not recommended.
Contrave has two components: naltrexone, an opioid antagonist, and bupropion, a relatively weak inhibitor of the neuronal reuptake of dopamine and norepinephrine. Nonclinical studies suggest that naltrexone and bupropion have effects on two separate areas of the brain involved in the regulation of food intake: the hypothalamus (appetite regulatory center) and the mesolimbic dopamine circuit (reward system). The exact neurochemical effects of Contrave leading to weight loss are not fully understood.
In the U.S. general population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2-4% and 15-20%, respectively.
In clinical studies, 21 (0.7%) of 3,024 women became pregnant while taking Contrave: 11 carried to term and gave birth to a healthy infant, three had elective abortions, four had spontaneous abortions, and the outcome of three pregnancies were unknown.
However, Contrave should not be taken with a high-fat meal because of a resulting significant increase in bupropion and naltrexone systemic exposure [see Warnings and Precautions ( 5.3) and Clinical Pharmacology ( 12.3 )].
The major metabolite of naltrexone is 6-beta-naltrexol. The activity of naltrexone is believed to be the result of both the parent and the 6-beta-naltrexol metabolite. Though less potent, 6-beta-naltrexol is eliminated more slowly and thus circulates at much higher concentrations than naltrexone. Naltrexone and 6-beta-naltrexol are not metabolized by cytochrome P450 enzymes and in vitro studies indicate that there is no potential for inhibition or induction of important isozymes.
Contrave contains bupropion, a dopamine and norepinephrine re-uptake inhibitor that is similar to some drugs used for the treatment of depression; therefore, the following precautions pertaining to these products should be considered when treating patients with Contrave.
Wegovy ™ contains semaglutide and should not be used with other semaglutide-containing products or other GLP-1 receptor agonist medicines. It is not known if Wegovy ™ is safe and effective when taken with other prescription, over-the-counter, or herbal weight loss products.
increased risk of low blood sugar (hypoglycemia) in patients with type 2 diabetes, especially those who also take medicines for type 2 diabetes such as sulfonylureas or insulin. This can be both a serious and common side effect.